快速或很少被隔离的阴性杆,特别关注金格拉王
Reinhard Zbinden1, Pablo Yagupsky2
1BSc Biomedical Laboratory Diagnostics, Institute of Chemistry and Biotechnology, Zurich University of Applied Sciences, Wädenswil, Switzerland.
Clinical microbiology reviews
|September 25, 2025
概括
金氏菌是儿童感染的关键原因,如细菌病和骨髓炎. 分子诊断的进步有助于区分殖民和感染,并识别与K. kingae相关的新型疾病.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
背景情况:
- 金氏菌 (Kingella kingae) 是小儿细菌病,骨髓炎和败血性关节炎的重要病原体.
- 最近的分子诊断进展为K. kingae病原和传播提供了新的见解.
研究的目的:
- 审查Kingella kingae和相关细菌属的临床和微生物学的方面.
- 突出K. kingae感染的诊断和理解方面的进展.
主要方法:
- 关于金格拉王和其他相关品种的最新文献的综述.
- 讨论分子诊断技术,包括16S核糖体RNA基因PCR/测序和MALDI-TOFMS.
- 对表型识别方法及其局限性的分析.
主要成果:
- 现在可以区分无症状的耳鼻结殖和侵入性K. kingae感染.
- 已经确定了由K. kingae引起的新型和不常见的感染.
- 准确识别不常见的分离物通常需要分子方法.
结论:
- 分子方法对于准确识别K. kingae和相关细菌至关重要,特别是对于不常见的分离物.
- 这些苛刻的グラム阴性杆菌的抗生素耐药性需要进行敏感性测试以获得有效的治疗.
- 了解混合感染和临床表现指导抗生素选择.
相关概念视频
Bacterial Phylum Bacteroidota
589
The phylum Bacteroidota includes over 700 species classified into four primary orders: Bacteroidales, Cytophagales, Flavobacteriales, and Sphingobacteriales. These gram-negative, non-sporulating rods exhibit saccharolytic capabilities and can be aerobic or fermentative, encompassing obligate aerobes, facultative aerobes, and obligate anaerobes. Many species display gliding motility, though some are nonmotile or use flagella. The genus Bacteroides is well-studied due to its significant role in...
589
Bacterial Phylum Actinobacteria
616
Coryneform bacteria are gram-positive, aerobic, nonmotile rods that exhibit irregular, club-shaped, or V-shaped arrangements. Their V-shape results from snapping division, where the inner cell wall layer forms the cross-wall, while the outer layer remains intact until it ruptures on one side, causing the daughter cells to bend away.The primary genera are Corynebacterium and Arthrobacter. Corynebacterium includes diverse species, ranging from saprophytes to pathogens like Corynebacterium...
616
Bacterial Phylum Spirochaetes
594
Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased...
594
Other Unique Bacteria
418
Magnetic bacteria exhibit a directed movement called magnetotaxis, driven by structures called magnetosomes. These magnetosomes consist of chains of magnetic particles made of either magnetite (Fe₃O₄) or greigite (Fe₃S₄) and are organized in a linear conformation by a protein scaffold within invaginations of the cell membrane. The bacteria align along the north–south magnetic field lines, much like a compass needle. They are typically microaerophilic or anaerobic...
418
Diversity of Protists I
861
Excavata is a diverse group of protists that includes both chemoorganotrophic and phototrophic species, with some thriving in anaerobic environments. Among the key groups within Excavata are diplomonads and parabasalids, which are flagellated protists that lack mitochondria and chloroplasts. These microorganisms typically inhabit anoxic environments, such as the intestines of animals, where they exist either symbiotically or as parasites, relying on fermentation for energy production. Some...
861
Bacterial Phylum Proteobacteria
785
Proteobacteria, one of the largest and most diverse bacterial phyla, encompasses a wide range of Gram-negative bacteria distinguished by their outer membrane composed of lipopolysaccharides. These microorganisms exhibit various metabolic capabilities, including phototrophy, chemolithotrophy, and heterotrophy, and thrive in diverse environments from soil to aquatic systems and host-associated niches. The phylum is divided into six classes: Alphaproteobacteria, Betaproteobacteria,...
785


