研究维生素A和维生素E水平与新生儿免疫功能和死角性肠球炎之间的相关性
Jing Ma1, Zhexia Hu2, Weina Liu1
1Department of Neonatal, Shijiazhuang No.4 Hospital, Shijiazhuang, Hebei Province, China.
Pakistan journal of pharmaceutical sciences
|September 25, 2025
概括
维生素A (VA) 和维生素E (VE) 补充剂改善了免疫功能,并降低了早产婴儿死性肠球炎 (NEC) 风险. 联合VA和VE为婴儿健康提供了最显著的好处.
科学领域:
- 新生儿科学 新生儿科学
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 维生素A (VA) 和维生素E (VE) 缺乏症在早产婴儿中很普遍.
- 这些缺陷可能会损害免疫功能,并增加死性肠球炎 (NEC) 的风险.
研究的目的:
- 研究维生素A和E水平与新生儿免疫状况之间的关系.
- 评估VA和VE补充剂对免疫标记物和早产婴儿NEC发病率的影响.
主要方法:
- 这项研究涉及2022-2024年期间的220名早产婴儿.
- 婴儿被分配到VA,VE,VA+VE补充剂或对照组.
- 在补充剂服用一个月之前和之后评估VA,VE水平和T淋巴细胞子集.
主要成果:
- 补充组显示VA和VE水平显著增加 (P<0.05).
- 免疫功能标志物得到改善,特别是在VA+VE组 (P<0.05).
- VA+VE组表现出最低的NEC发病率 (1.82%,P=0.031),较高的VA/VE水平与更好的免疫力和较低的NEC风险相关 (P<0.05).
结论:
- 新生儿免疫功能和NEC发生与维生素A和E度密切相关.
- 补充维生素A和维生素E,有望预防早产新生儿的NEC.
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