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Updated: May 1, 2026

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了解in-vivo和in-silico鼻腔测量之间的不匹配情况

Marco Atzori1, Gabriele Dini Ciacci2, Maurizio Quadrio3

  • 1Department of Aerospace Science and Technology, Politecnico di Milano, Campus Bovisa, Milano, 20156, Italy. marco.atzori@polimi.it.

Medical & biological engineering & computing
|September 25, 2025
PubMed
概括

模拟和临床设备之间的鼻腔阻力测量的差异可能源于探头在鼻力计上的放置. 这个设备的设计缺陷,而不是模拟不确定性,显著影响了鼻电阻数据的准确性.

关键词:
计算流体动力学 计算流体动力学鼻腔阻塞 鼻腔阻塞 鼻腔阻塞鼻腔阻力 鼻腔阻力鼻腔测量术 (Rhinomanometry) 是一种鼻腔测量术.

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In pharmaceutical development, it's crucial to establish a predictive in vitro–in vivo correlation (IVIVC) for two or more formulations to gain a comprehensive understanding of release properties. IVIVC reduces the need for costly in vivo studies and facilitates the establishment of meaningful dissolution specifications with significant cost savings and decreased regulatory burden. Furthermore, a meaningful IVIVC should predict Cmax and AUC within 20%, aligning with FDA guidance while...
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