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Updated: Jan 6, 2026

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

解码与NF-κB通路相关的循环RNAs在致癌过程中的功能性作用

Wei Wang¹, Kang Zheng¹, Zhi Feng²

¹Affiliated Hengyang Hospital of Hunan Normal University & Hengyang Central Hospital, Hengyang, 421001, Hunan, China.

Discover oncology

|September 25, 2025

概括

循环RNAs (circRNAs) 是癌症NF-κB通路的关键调节者. 本综述详细介绍了circRNAs如何影响癌症过程及其作为生物标志物和治疗点的潜力.

科学领域:

分子生物学分子生物学
遗传学遗传学是一个
在瘤学瘤学.

背景情况:

循环RNA (circRNAs) 是非编码RNA,在基因调节中起着至关重要的作用.
核因子kappa B (NF-κB) 信号通路是参与癌症发展的细胞过程的关键调节者.
新出现的证据突出显示,circRNAs在致癌过程中参与调节NF-κB途径.

研究的目的:

审查目前对癌症NF-κB信号通路的circRNA调节的理解.
探索circRNAs调节NF-κB活动的功能机制.
讨论circRNAs作为生物标志物和各种癌症类型的治疗点的临床相关性.

主要方法:

对近期关于circRNAs和癌症NF-κB通路的研究进行文献综述.
分析circRNA功能,包括miRNA海绵,蛋白相互作用和翻译.
对circRNA表达与临床病理特征和患者结果的相关性分析.

主要成果:

循环RNAs充当NF-κB途径的关键调节者,影响癌症特征,如增殖,入侵,亡和免疫逃逸.
功能机制包括miRNA海绵化,直接蛋白质结合和转化为,所有这些都汇聚在NF-κB活性上.
与NF-κB相关的circRNAs的表达水平与瘤阶段,转移和患者存活率相关.

结论:

环RNA/NF-κB轴是癌症生物学中的重要参与者,影响多种瘤过程.
与NF-κB相关的circRNAs显示出作为癌症的诊断和预后生物标志物的潜力.
针对参与NF-κB信号传递的circRNAs,为新型癌症疗法提供了一个有希望的途径.

关键词:

生物标志物生物标志物癌症癌症癌症癌症循环RNA 是一个循环RNA.功能功能功能功能机理机制机理机制在 NF-κBB 中.

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