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多微生物血流感染的特征,发病率和结果:一项基于全国人口的全国性研究,芬兰,2004-2018年
Keiju S K Kontula1, Kirsi Skogberg2, Jukka Ollgren3
1Division of Infectious Diseases, Inflammation Center, Helsinki University Hospital and University of Helsinki, P.O. Box 340, Helsinki, 00029 HUS, Finland. keiju.kontula@hus.fi.
Infection
|September 25, 2025
概括
从2004年到2018年,多微生物血流感染 (BSI) 的发生率翻了一番. 这些感染在伴随疾病的老年人中更为常见,死亡率明显高于单微生物BSI.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 血流感染 (BSI) 是死亡的一个重要原因.
- 多微生物BSI与单微生物BSI相比,患者的治疗结果更差.
研究的目的:
- 分析芬兰多微生物BSI发病率和结果的患者特征和时间趋势.
- 将多微生物BSI与单微生物BSI的结果进行比较.
主要方法:
- 利用2004-2018年的国家注册数据来识别BSI.
- 确定感染来源,患者的并发症 (查尔森并发症指数) 和BSI的30天死亡率.
- 计算了单微生物和多微生物BSI的发病率和病例死亡率.
主要成果:
- 多微生物性BSI占所有BSI的6.5%,常见的病原体包括大肠杆菌,肠球菌和Klebsiella sp.
- 聚细菌性BSI的发病率从每10万人口中的9.7个增加到21.8个,特别是在90岁及以上的个体中.
- 多微生物BSI的30天病例死亡率为20.6%,明显高于单微生物BSI的12.4%.
结论:
- 在2004年至2018年期间,多微生物BSI的发病率翻了一番,这表明公共卫生问题越来越严重.
- 在多微生物BSI中,较高的死亡率与老年患者的年龄和增加的并发症负担有关.
- 强调早期识别有风险的患者至关重要,以优化BSI的经验治疗策略.
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