患者报告的功能益处在地理缩中的重要性
Christiana Dinah1,2, Jamie Enoch3, Arevik Ghulakhszian1
1Ophthalmology Department, Central Middlesex Hospital, London North West University Healthcare National Health Service Trust, London, United Kingdom.
JAMA ophthalmology
|September 25, 2025
概括
如果预计有视力益处,大多数英国地理缩 (GA) 患者可以接受内补充抑制剂注射 (IVCI). 患者对治疗有效性的信念和定期上诊与接受度有积极的相关性.
科学领域:
- 眼科医生 眼科 眼科
- 医学治疗学 医学治疗学
- 患者报告的结果
背景情况:
- 内补充抑制剂注射 (IVCI) 在临床试验中显示出减缓地理缩 (GA) 进展的前景.
- 然而,这些治疗方法对二次功能视觉结果没有显著的益处.
- 患者接受IVCI需要进一步调查,特别是关于感知到的益处.
研究的目的:
- 量化IVCI治疗在被诊断患有GA的英国患者中的可接受性.
- 评估患者对与IVCI治疗相关的视力结果益处的期望.
- 探索影响患者接受IVCI治疗GA的因素.
主要方法:
- 在英国9个国家卫生服务中心进行了一项横截面研究.
- 在2023年4月至2024年4月期间,招募了153名患有GA的未经治疗的参与者.
- 可接受性是使用验证的问卷和EuroQol 5维测量与视觉螺栓对生活质量评估进行测量.
主要成果:
- 在理论情景下,超过一半的参与者 (53%) 认为IVCI在理论情景下非常或非常可接受.
- 当包括适度可接受的反应时,可接受性增加到82%.
- 感知治疗有效性 (ρ=0.52) 和对定期诊所出院的信心 (ρ=0.51) 与整体可接受性有显著的相关性.
结论:
- 对GA的IVCI治疗对大多数英国患者来说可能是可以接受的,只要有预期的视力结果好处.
- 患者报告的感知有效性是可接受性的关键驱动因素,强调需要将解剖学益处与功能视觉改善相协调.
- 这些发现强调了患者观点在采用新型眼科治疗GA时的重要性.
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