在学龄前儿童诊断前视障碍时使用阿特罗平或环环酸盐
Haotian Wu1,2, Yanjiao Wang1, Qiuying Lu1
1Shanghai Eye Diseases Prevention and Treatment Center/Shanghai Eye Hospital, School of Medicine, Tongji University, Shanghai, China.
JAMA ophthalmology
|September 25, 2025
概括
在学龄前儿童的阿特罗平环导致较少的近视折射与环酸相比. 这一发现可能有助于防止在年轻患者中高估前视障碍.
科学领域:
- 眼科医生 眼科 眼科
- 儿科光学测量 儿科光学测量
背景情况:
- 对幼儿的精确折射误差评估对于及时诊断和干预至关重要.
- 循环的药物对于在学龄前儿童中达到足够的循环是必不可少的.
- 选择循环体剂可以影响客观的折射结果和随后的诊断结论.
研究的目的:
- 为了比较学龄前儿童的客观折射结果,随着由阿特罗平或环酸诱导的循环.
- 评估不同循环损伤剂对幼儿各种折射状态的流行影响.
主要方法:
- 使用两个基于人群的研究数据进行了后期分析:PRDP-IFS (阿特罗宾) 和E-SCORDS (cyclopentolate).
- 倾向性得分匹配用于从每个研究组中选择可比眼睛.
- 客观折射,包括球形等价和折射状态 (超视,前视,近视),在循环后使用自折射器确定.
主要成果:
- 在非cycloplegic和cycloplegic状态之间,球体等效 (DSE) 的平均差异在阿特罗平组 (1.56 D) 与环酸组 (0.97 D) 相比显著更大.
- 与循环托酸盐组相比,阿特罗平组的中度至高高视度 (7.2%对2.7%) 和低高视度 (82.8%对74.0%) 的患病率较高.
- 相反,环托酸盐组表现出更高的前视障碍 (21.6%对比8.7%) 的患病率,而不是氨酸组.
结论:
- 在学龄前儿童中,阿特罗平诱导的循环与较少的近视折射结局有关,与循环酸相比.
- 使用阿特罗平可能有助于缓解使用环醇观察到的潜在高估前视障碍的患病率.
- 需要进一步的研究,因为这项研究并没有直接比较同一组儿童中的两种药物.
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