在noradrenergic神经系统上起作用的FGF21可以防止流感病毒感染
Wei Fan1, Yuan Zhang1, Laurent Gautron2
1Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
概括
纤维细胞生长因子21 (FGF21) 通过调节能量消耗和体温来防止流感感染. FGF21的使用改善了小鼠的结果,突出了其治疗潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
背景情况:
- 纤维细胞生长因子21 (FGF21) 是一种已知的受感染诱导的激素.
- 它在病毒感染,特别是流感中的作用尚未完全理解.
研究的目的:
- 研究FGF21在小鼠和人类流感病毒感染中的作用.
- 探索FGF21保护作用的潜在神经元机制.
主要方法:
- 研究了FGF21诱导在人类和小鼠的流感反应.
- 使用了FGF21淘汰赛小鼠和小鼠缺乏βKlotho在noradrenergic神经元.
- 在感染后药理学上给予FGF21.
- 进行了对养研究,以评估食物摄入的影响.
- 检查了棕色脂肪组织和神经元活动中的基因表达.
主要成果:
- 在人类和小鼠中,FGF21是由流感病毒感染引起的.
- FGF21淘汰赛小鼠对流感的耐受性降低,食物摄入量,体重和体温降低.
- 药物学FGF21的使用保护了小鼠免受流感诱导的病理.
- 缺乏FGF21核心受体βKlotho在诺亚上神经元中的小鼠更容易感染.
- 通过noradrenergic神经元,FGF21在棕色脂肪组织中刺激能量消耗和发热基因表达.
结论:
- 在流感病毒感染期间,FGF21起着关键的保护作用.
- 一个由FGF21调节的神经元通路涉及诺拉德尼基神经元,增强了宿主防御.
- FGF21代表了一种潜在的治疗剂,可以改善流感感染的结果.
关键词:
FGF21FGF21FGF21FGF21FGF21FGF21FGF21FGF21FGF21FGF21F能源支出 能源支出流感 流感 流感 流感 流感诺拉德仁基神经系统 诺拉德仁基神经系统克洛托 (βKlotho) 是一种更多相关视频
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