采用细胞治疗中的自然杀手细胞:基因工程策略的当前景观

María Burón1,2, Anne Etxebarria1,2,3,4, Maite Álvarez1,2,3,4

  • 1Cell Therapy, Stem Cells and Tissues Group, Biobizkaia Health Research Institute, Barakaldo, Spain.

Oncoimmunology
|September 25, 2025
PubMed
概括

自然杀手 (NK) 细胞疗法为癌症治疗提供了一个比CAR-T细胞疗法更安全的替代方案,避免细胞因子释放综合征和移植与宿主疾病. 基因工程增强了抗瘤NK细胞的功能,克服了瘤微环境的局限性.

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Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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