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相关概念视频

Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
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Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

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Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
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Primary Lymphoid Organs01:16

Primary Lymphoid Organs

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Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
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Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

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The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
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Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

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Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
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Development of the Lymphatic System01:15

Development of the Lymphatic System

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The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
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相关实验视频

Updated: Jan 17, 2026

Collection and Processing of Lymph Nodes from Large Animals for RNA Analysis: Preparing for Lymph Node Transcriptomic Studies of Large Animal Species
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Collection and Processing of Lymph Nodes from Large Animals for RNA Analysis: Preparing for Lymph Node Transcriptomic Studies of Large Animal Species

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跨器官的三级淋巴体结构:背景,组成和临床杆

Stephane M Guillaume1, Cristian G Beccaria2,3, Matteo Iannacone2,3,4

  • 1Immunology Program, Babraham Institute, Cambridge, UK.

Immunological reviews
|September 25, 2025
PubMed
概括

在慢性炎症期间,三级淋巴体结构 (TLS) 在非淋巴体组织中形成. 本综述涵盖了它们的形成,功能,在疾病中的临床相关性,以及用于治疗向的新型高分辨率分析方法.

关键词:
B 细胞 B 细胞 B 细胞发芽中心是生殖中心.三级淋巴状结构的第三级淋巴状结构

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Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy
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Isolation of Murine Lymph Node Stromal Cells
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相关实验视频

Last Updated: Jan 17, 2026

Collection and Processing of Lymph Nodes from Large Animals for RNA Analysis: Preparing for Lymph Node Transcriptomic Studies of Large Animal Species
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Published on: May 19, 2018

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Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy
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科学领域:

  • 免疫学 免疫学 免疫学
  • 病理学 病理学 病理学
  • 细胞生物学 细胞生物学

背景情况:

  • 三级淋巴体结构 (TLS) 是在慢性炎症和持续的抗原暴露期间在非淋巴体组织中发现的免疫细胞聚合物.
  • TLS表现出一系列的发展,从简单的免疫细胞群到具有功能生殖中心 (GC) 的有组织结构.

研究的目的:

  • 提供对三级淋巴细胞结构 (TLSs) 的形成,架构和功能在各种组织中的综合性审查.
  • 探索TLS在健康和疾病中的临床意义和双重作用,包括感染,自身免疫,癌症和过敏.
  • 讨论用于高分辨率TLS分析和治疗调制的新兴技术.

主要方法:

  • 文献综述和对TLS现有研究的综合.
  • 在各种组织环境中分析TLS的形成,结构和功能.
  • 探索将TLS与各种病理和免疫反应联系起来的临床数据.

主要成果:

  • 在许多器官中发现的TLS在成熟度和组织上有所不同,具有共同的和组织特异性的特征.
  • TLS在疾病中起着复杂的作用,有助于保护免疫和病理过程.
  • 诸如空间多态学和数字病理学等先进技术为剖析TLS生物学提供了新的途径.

结论:

  • 了解TLS成熟和组织背景对于解释它们的临床关联至关重要.
  • 在各种疾病中,TLS代表调节免疫反应的潜在治疗点.
  • 新兴的高分辨率技术将推动TLS向疗法的研究和临床应用.