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牛皮的参与者异质性干预试验

Shuntong Kang^1,2,3,4,5,6, Dingyao Zhang⁷, Bo Zhang³

¹Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.

Dermatology (Basel, Switzerland)

|September 25, 2025

概括

牛皮随机临床试验 (RCT) 的参与者异质性受到国家收入的显著影响. 低收入国家的试验通常显示参与者的坚持更好,影响全球干预效率.

科学领域:

皮肤病学皮肤病学
临床试验临床试验
卫生经济学卫生经济学

背景情况:

参与者的异质性会影响临床试验中的干预疗效.
在牛皮随机临床试验 (RCT) 中推动参与者异质性的因素尚不清楚.
参与者坚持是RCT中异质性的关键指标.

研究的目的:

在牛皮RCT中探索参与者的异质性,重点关注参与者的坚持.
识别影响不同国家收入水平参与者坚持学习的因素.

主要方法:

在2021年7月之前对干预性牛皮RCT进行系统的文献搜索.
包括来自数据库和注册表的同行评审文章和注册试验.
进行元分析以计算参与者在干预组和对照组之间坚持的风险比率.

主要成果:

1,714项试验符合纳入标准;国民收入对提款率产生了独特的影响.
参与者的坚持因国家国民收入而有很大差异.
与高收入国家相比,低收入和中等收入国家的试验表现出更好的坚持和更稳定的退出比率.

结论:

国家收入是全球牛皮RCT参与者异质性的意想不到的驱动因素.
由于混因素,高收入国家的结果需要仔细解释.
严格的单一国家试验对于制定本地化临床管理策略至关重要.

关键词:

异质性异质性异质性国家收入国家收入.牛皮是一个病.随机临床试验随机临床试验全球范围全球范围全球范围

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