来自Isodon serra的两个新型体及其对抗阿尔茨海默病的活性
Li-Jia Ye1, Miao Zhang1, Mi-Na Yang1
1School of Pharmacy and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, People's Republic of China.
Chemistry & biodiversity
|September 25, 2025
概括
研究人员发现了两种新的化合物,异素A和异酸A,来自Isodon serra. 一些化合物在C. elegans模型中显示出延迟阿尔茨海默病进展的潜力.
科学领域:
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
- 分子生物学分子生物学
背景情况:
- 伊索登塞拉 (Lamiaceae) 是一种具有潜在药用功能的植物物种.
- 自然产品是新型治疗剂的丰富来源.
- 阿尔茨海默病 (AD) 仍然是一个重要的全球健康挑战,治疗选择有限.
研究的目的:
- 从Isodon serra.中分离和描述新的化学成分.
- 为了研究孤立化合物的体内抗阿尔茨海默病潜力.
主要方法:
- 使用 95% 乙醇提取物的植物化学研究 Isodon serra.
- 通过HRESIMS,IR,1D和2DNMR光谱学阐明结构.
- 使用电子圆形二重化 (ECD) 和单晶X射线衍射来确定绝对配置.
- 在体内对抗AD活性进行评估,使用转基因C. elegans (C. elegans) AD模型 (CL4176线虫).
主要成果:
- 隔离了一种新的ent-kaurane二烯酸 (isoerrone A) 和一种新的2,3-seco-ursane型三烯酸 (isoerric acid A).
- 描述了四种已知的化合物 (3-6),其中化合物1-3,5和6首次从I. serra中报告.
- 对于已知化合物4-6的首次报告的单晶X射线衍射数据.
- 化合物3和6在100μM的C. elegansAD模型中显著延迟了,表明了抗AD作用.
结论:
- 伊索登塞拉是新型二甲和三甲化合物的来源.
- 化合物3和6在体内表现出有希望的抗阿尔茨海默病活性.
- 这些发现表明这些化合物的潜在治疗应用在AD治疗中.
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