Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Genetic Variation01:25

Genetic Variation

1.2K
Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles,...
1.2K
Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

18.6K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
18.6K
Incomplete Dominance01:43

Incomplete Dominance

29.6K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
29.6K
Longitudinal Studies01:26

Longitudinal Studies

479
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
479
Three-Dimensional Analysis of Strain01:29

Three-Dimensional Analysis of Strain

585
Three-dimensional strain analysis is crucial for understanding how materials deform under stress, particularly in elastic, homogeneous materials. This method employs principal stress axes to simplify complex stress states into more understandable forms. Subjected to stress, a small cubic element within a material either expands or contracts along these axes, transforming into a rectangular parallelepiped. This transformation effectively illustrates the material's deformation. The principal...
585
Pedigree Analysis01:35

Pedigree Analysis

88.8K
Overview
88.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Postural Stability Changes During the 4 Phases of the Half Squat: Kinematics Profile of the Center of Pressure and Center of Mass in High-Performance Weightlifters-A Pilot Study.

Bioengineering (Basel, Switzerland)·2026
Same author

Serum Calcium Concentration Is Associated with Bone Mineral Density and Synonymous Variants in the <i>RYR1</i> Gene in a Mexican-Mestizo Population.

Medical sciences (Basel, Switzerland)·2025
Same author

EWAS in COPD by biomass-burning smoke exposure identifies low levels of endothelin-1 by hypermethylation of EDN1.

Epigenomics·2025
Same author

Half Squat Mechanical Analysis Based on PBT Framework.

Bioengineering (Basel, Switzerland)·2025
Same author

Somatotype, anthropometric characteristics, body composition, and global flexibility range in artistic gymnasts and sport hoop athletes.

PloS one·2024
Same author

mtDNA Single-Nucleotide Variants Associated with Type 2 Diabetes.

Current issues in molecular biology·2023

相关实验视频

Updated: Jan 17, 2026

Incremental Temperature Changes for Maximal Breeding and Spawning in Astyanax mexicanus
06:36

Incremental Temperature Changes for Maximal Breeding and Spawning in Astyanax mexicanus

Published on: February 14, 2021

4.4K

在十个墨西哥原住民和混血裔人口中,基于高密度LD的结构变异分析.

Adriana Griselda Mateos-Valenzuela1, Mirvana Elizabeth González-Macías2, Carlos Villa-Angulo1

  • 1Laboratory of Bioinformatics and Biophotonics, Engineering Institute, Autonomous University of Baja California, Mexicali, Baja California, México.

PloS one
|September 25, 2025
PubMed
概括

这项研究使用SNP数据对墨西哥人口的结构变异 (SV) 进行了表征. 这些SV反映了人口历史,可能与墨西哥的肥胖和糖尿病等疾病有关.

更多相关视频

Following the Dynamics of Structural Variants in Experimentally Evolved Populations
04:52

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

1.3K
Raising the Mexican Tetra Astyanax mexicanus for Analysis of Post-larval Phenotypes and Whole-mount Immunohistochemistry
06:42

Raising the Mexican Tetra Astyanax mexicanus for Analysis of Post-larval Phenotypes and Whole-mount Immunohistochemistry

Published on: December 28, 2018

9.7K

相关实验视频

Last Updated: Jan 17, 2026

Incremental Temperature Changes for Maximal Breeding and Spawning in Astyanax mexicanus
06:36

Incremental Temperature Changes for Maximal Breeding and Spawning in Astyanax mexicanus

Published on: February 14, 2021

4.4K
Following the Dynamics of Structural Variants in Experimentally Evolved Populations
04:52

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

1.3K
Raising the Mexican Tetra Astyanax mexicanus for Analysis of Post-larval Phenotypes and Whole-mount Immunohistochemistry
06:42

Raising the Mexican Tetra Astyanax mexicanus for Analysis of Post-larval Phenotypes and Whole-mount Immunohistochemistry

Published on: December 28, 2018

9.7K

科学领域:

  • 基因组学就是基因组学.
  • 人口遗传学 人口遗传学
  • 生物信息学是一种生物信息学.

背景情况:

  • 结构变异 (SVs) 对于理解基因组多样性和进化至关重要.
  • 链接不平衡 (LD) 模式,特别是单核酸多态 (SNP) 之间的链接不平衡,可以揭示人口结构和人口历史.
  • 墨西哥人口表现出独特的遗传多样性,受当地人和梅斯蒂索祖先的影响.

研究的目的:

  • 在10个墨西哥土著和混血人口中对结构变异 (SVs) 进行全基因组的表征.
  • 调查基于SNP的链接不平衡 (LD) 推断的SV与人口结构之间的关系.
  • 为了确定与墨西哥人口中普遍存在的健康状况相关的潜在VS.

主要方法:

  • 利用了来自10个墨西哥人口的383个个体的SNP基因型化数据.
  • 分析了单核酸多态体 (SNP) 之间预期的短距离连接不平衡 (LD) 的偏差,以确定SVs.
  • 将已识别的SV与基因进行映射,以评估其潜在的功能和健康相关影响.

主要成果:

  • 在10个种群中确定了4,375个结构变异,平均每种群19,438个SNP.
  • 标志着从2845到8646kb的平均SVP大小,平均每SVP有50.14个SNP.
  • 发现了506个不同的SV区域,其中54个区域是所有10个种群的共同体,并确定了8443个受这些变异影响的基因,包括与肥胖和糖尿病相关的FTO,ABCA1和ELMO1.

结论:

  • 通过SNP-LD偏差检测到的SVs有效地捕获了人口结构和人口历史.
  • 这些已识别的SVs代表了了解墨西哥人口中人口特异性疾病的潜在目标.
  • 这项研究为未来研究墨西哥健康和疾病的遗传基础提供了宝贵的基因组资源.