在动物中定义HFpEF:系统性审查
Yamen Adrah1,2, Niklas Hegemann1,2,3, David Faidel1,2,3
1Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité (DHZC), Augustenburger Platz 1, Berlin 13353, Germany.
Cardiovascular research
|September 25, 2025
概括
许多研究使用动物模型来研究心力衰竭与保存的喷射分数 (HFpEF),但超过40%缺乏足够的证据来支持HFpEF标签. 在HFpEF研究中,仔细审查表型文档至关重要.
科学领域:
- 心血管研究研究心血管研究
- 翻译医学是一种翻译医学.
- 临床前模型 临床前模型
背景情况:
- 保存喷射分数 (HFpEF) 的心力衰竭是心力衰竭的流行亚型,治疗选择有限.
- 临床前研究在很大程度上依赖于动物模型来研究HFpEF,需要验证它们的临床准确性.
- 现有的HFpEF动物模型可能不一致反映已建立的临床诊断指南.
研究的目的:
- 评估标有"HFpEF"的动物模型与当前临床诊断指南相一致的程度.
- 评估HFpEF研究中常用的临床前模型的表型准确性.
- 为了确定动物研究和临床定义中声称的HFpEF表型之间的潜在差异.
主要方法:
- 在PubMed数据库上对2008年至2023年间发表的研究进行了系统的文献搜索.
- 确定了475项使用HFpEF动物模型的研究;N=407篇使用标有"HFpEF"的小鼠或老鼠的原始研究文章被分析.
- 评估了317个实验组与预定义的诊断集群,这些集群来源于欧洲心脏病学会HF指南.
主要成果:
- 只有57% (N=179) 的被标记为"HFpEF"的实验组符合基于临床指南的推证据标准.
- 在动物模型中,很大一部分研究 (约43%),未能为"HFpEF"名称提供足够的证据.
- 更高的期刊影响因子和更近期的出版日期与研究符合HFpEF标准的概率呈正相关.
结论:
- 相当数量的临床前研究错误标记或不充分记录动物模型中的HFpEF表型.
- 读者和评论者应谨慎行事,并严格评估HFpEF动物研究中的表型文档.
- 需要提高HFpEF动物模型的标准化和验证,以确保可靠的临床应用.
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