Lysosomes 通过表观基因组发出信号来调节跨代的寿命
Qinghao Zhang1, Weiwei Dang1, Meng C Wang1,2
1Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA.
Science (New York, N.Y.)
|September 25, 2025
概括
Lysosomes 通过表观基因组发出信号来控制虫的几代寿命. 这涉及从肠道转移到生殖线,从而跨代延长寿命.
科学领域:
- 表观遗传学
- 分子生物学
- 老年学
背景情况:
- 表观基因组影响衰老,并对代谢信号作出反应.
- 溶酶体是感知新陈代谢和调节寿命的关键细胞中心.
研究的目的:
- 研究溶酶体代谢途径如何影响表观基因组和跨代寿命.
- 识别链接 lysosomal 信号与遗传寿命延长的分子机制.
主要方法:
- 我研究了一种线虫,
- 操纵了溶酶体信号通路 (脂质信号,AMPK,mTOR).
- 分析了基因组H3.3变体表达,H3K79甲基化和体细胞和生殖细胞之间的基因组传输.
主要成果:
- 激活溶解体脂质信号或AMPK,或减少mTOR,延长了多代人的寿命.
- 这些干预措施增加了基因组H3. 3变体表达和H3K79甲基化.
- 跨代寿命延长取决于H3. 3和生殖系H3K79甲基转移酶的从肠到生殖系的传输.
结论:
- Lysosomal代谢途径在表观遗传上调节了跨代长寿.
- 基因组H3.3及其甲基化介导着长寿的遗传.
- 表观遗传信息的 Soma-to-germline 通信将溶解体与遗传寿命联系在一起.
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