相关实验视频

Updated: Jan 16, 2026

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma

Published on: March 3, 2023

在肺癌中通过TRPM4通道调制释放alpha-phellandrene的抗癌作用

Akanksha Singh¹, Shristi Modanwal², Abha Meena¹

¹Bioprospection and Product Development Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, Uttar Pradesh 226015, India; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh 201002, India.

Computational biology and chemistry

|September 25, 2025

概括

这项研究探讨了用于肺癌治疗的天然化合物. 作为TRPM4抑制剂,α-phellandrene显得有前途,可能导致新的非小细胞肺癌治疗方法.

科学领域:

在瘤学瘤学.
药理学药理学是指药理学的学科.
生物物理学的生物物理.

背景情况:

非小细胞肺癌 (NSCLC) 是癌症死亡的主要原因.
向疗法提供精确的治疗,副作用较少.
离子通道,特别是短暂受体潜在拉斯 (TRPM) 通道,与肺癌的进展和对亡的抵抗有关.

研究的目的:

研究自然存在的单烯作为TRPM通道的调节剂,用于潜在的肺癌治疗.
评估单二烯与特定TRPM异型的药物相似性和结合亲和力.

主要方法:

在中选15个单烯的药理动力学特性 (ADMET) 和药物相似性.
对TRPM2,TRPM4,TRPM5,TRPM7和TRPM8进行分子对接研究.
分子动力学模拟以评估复杂的稳定性.

主要成果:

阿尔法 - 费兰德伦对TRPM4 (-6.0 kcal/mol) 显示出显著的结合亲和力.
阿尔法-费兰德烯与已知的TRPM4抑制剂共享关键结合残留物.
分子动力学模拟证实了TRPM4-alpha-phellandrene复合物的稳定性.

结论:

阿尔法-兰是一种有前途的自然化合物,用于向TRPM4.
这一发现表明,有可能开发用于肺癌的新型TRPM4向疗法.

关键词:

阿尔法 - 菲兰德里尼信号传递的.单烯是一种单烯.在NSCLCLC中,我们可以看到.TRPM4 TRPM4 在线播放

更多相关视频

Phospholipid Mediator Induced Transformation in Three-Dimensional Cultures

Phospholipid Mediator Induced Transformation in Three-Dimensional Cultures

Published on: July 27, 2022

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Adaptive Mechanisms in Cancer Cells

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...