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从查到风险评估:对产品使用,人类负担和新型类相似物潜在神经毒性的比较研究

Lingxue Meng¹, Hongxuan Kuang¹, Jianhua Tan²

¹Key Laboratory of Environmental Pollution Health Risk Assessment, Ministry of Ecology and Environment, South China Institute of Environmental Sciences, Ministry of Ecology and Environment, Guangzhou 510655, China.

Environment international

|September 25, 2025

概括

帕拉本类似物p-hydroxyacetophenone (PhAc) 在个人护理产品和儿童中广泛使用.

科学领域:

环境化学环境化学
毒理学毒理学毒理学
公共卫生公共卫生

背景情况:

类是常见的防腐剂,已知具有内分泌干扰作用和神经毒性.
对类药物的风险的担忧正在推动寻找替代品的研究,但其类似药物的患病率和健康影响尚未得到充分研究.
帕拉本类类似物可能会带来显著的,但不太了解的健康和环境风险.

研究的目的:

选个人护理产品 (PCP) 中的帕拉本类似物,并评估人口暴露.
调查p-hydroxyacetophenone (PhAc) 的患病率和潜在的神经毒性,这是一个已识别的类相似物.
评估与增加PhAc暴露相关的人类健康风险.

主要方法:

使用高分辨率质谱测试来选类比烯的类似物.
进行了PCP中PhAc的定量分析和儿童尿液的纵向生物监测 (2016-2023年).
在体外研究中,将神经元细胞暴露在PhAc和甲基上,以评估神经毒性.

主要成果:

p-hydroxyacetophenone (PhAc) 在儿童尿液和PCP中被确定为类比类比的类比,其度高于典型的类比.
纵向数据显示,儿童的尿液PhAc水平显著增加,比帕拉本高出数量级.
PhAc 显示出比甲基更大的神经毒性,破坏神经元细胞平衡,形态,甚至在低暴露水平上增加细胞亡.

结论:

PhAc是PCP中普遍存在的类类似物,人类暴露率明显高于类.
与甲基相比,PhAc具有更大的神经毒性,造成潜在的生态和人类健康风险.
进一步的研究对于理解和减轻与PhAc暴露相关的风险至关重要.

关键词:

孩子孩子孩子孩子神经毒性神经毒性非有针对性的查.这是一种P-hydroxyacetophenone.帕拉类型的类似物.个人护理产品个人护理产品

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