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Updated: Jul 21, 2026

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西格莱克14-TLR2轴在巨细胞中介导抗HIV-1免疫力

Minjuan Shi1, Beibei Lu1, Wudi Wei1

  • 1Guangxi Key Laboratory of AIDS Prevention and Treatment & School of Public Health, Guangxi Medical University, Nanning 530021, China.

International immunopharmacology
|September 25, 2025
PubMed
概括

西格莱克14蛋白自然地通过激活巨细胞中的免疫反应来保护HIV-1感染. 这一发现为HIV免疫疗法和疫苗开发提供了一个新的目标.

关键词:
艾滋病病毒-1 艾滋病病毒-1巨细胞是一个巨细胞.Siglec14 标志14 标志14 标志14 标志这就是TLR2信号.

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T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...