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Updated: Jun 12, 2026

Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma
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ZJK-807:KRASG12D的选择性PROTAC降解剂 克服胰腺癌中的抵抗

Zhaojuan Liu1, Heping Zheng1, Yanqing Tian1

  • 1Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong 266003, China.

Journal of medicinal chemistry
|September 25, 2025
PubMed
概括

一种新型的PROTAC药物ZJK-807有效降解胰腺癌细胞中的KRASG12D. 这种突破性的疗法克服了来自二次突变的抗性,为难以治疗的癌症提供了新的希望.

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