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Updated: Jan 16, 2026

Author Spotlight: Enhancing PSC-to-Functional Cell Differentiation Using ML Models Based on Live-Cell Bright-Field Imaging
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通过生成性深度学习识别一个最佳扰动来诱导所需的细胞状态

Younghyun Han1, Hyunjin Kim1, Chun-Kyung Lee1

  • 1Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.

Cell systems
|September 25, 2025
PubMed
概括

我们开发了PAIRING,这是一种深度学习工具,用于识别细胞干扰,以获得所需的细胞状态. 这种方法有助于理解基因表达变化,并具有治疗开发的潜力.

关键词:
细胞状态控制控制计算生物学是计算生物学.深度学习是一种深度学习.干扰识别 干扰识别系统生物学 系统生物学

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相关概念视频

Forced Transdifferentiation01:28

Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
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