相关实验视频

Updated: Jan 16, 2026

PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke

PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke

Published on: June 14, 2018

量化成像ATM:PET和autoradiography研究使用[C]AZD139090使用

Ramya Tokala¹, Chi-Hyeon Yoo¹, Joseph W Downey¹

¹Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.

ACS chemical neuroscience

|September 25, 2025

概括

该研究评估了 [11C]AZD1390 PET成像用于非人类灵长类动物的大脑ATM量化. 尽管存在潜在的流量问题,但研究结果支持在体内ATM测量的可行性.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
放射化学放射化学是指辐射化学.

背景情况:

ATAXIA-Telangiectasia突变 (ATM) 激酶对于DNA修复至关重要,也是治疗点.
一种ATM抑制剂AZD1390正在进行质母细胞瘤的临床试验.
碳-11标记为AZD1390 ([11C]AZD1390) 显示了大脑的穿透性.

研究的目的:

用PET在非人类灵长类动物中研究[11C]AZD1390的体内脑吸收和特定结合.
为了评估[11C]AZD1390与大脑中的ATM结合的和性.
评估使用PET成像测量大脑ATM水平的可行性.

主要方法:

在非人类灵长类动物中进行正子发射断层扫描 (PET) 成像.
在体内对非放射性AZD1390.0.进行自我竞争研究.
在实验室中使用非人类灵长类动物大脑组织进行自身放射.

主要成果:

在体内研究显示,有意想不到的放射性追踪剂吸收变化,这表明了外流机制.
[11C]AZD1390在实验室中证明了度依赖的,可和和可移位的结合.
观察到高亲和力 (Kd=0.23 nM) 和足够的Bmax (267.0 fmol/mg) 用于ATM量化.

结论:

[11C]AZD1390在灵长类大脑组织中表现出对ATM的高度亲和力.
虽然存在剂量非线性,但支持PET成像可行性用于体内ATM量化.
需要进一步的研究,以解决准确的ATM测量潜在的流量机制.

关键词:

[11C]AZD139090 的使用情况 ATAXIA-Telangiectasia 突变变异的发生在身体上自动辐射图像 (Autoradiography) 是一种自动辐射图像.动态建模运动建模定子发射断层扫描 (PET) 是一种定子发射断层扫描.无线电追踪器是什么意思

更多相关视频

A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat

A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat

Published on: December 28, 2013

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

相关概念视频

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...