瘤器官和瘤在芯片上配备下一代精密医学
Wentao Zhao1, Zilin Zhang1, Shihui Xu2
1State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, People's Republic of China.
Biofabrication
|September 25, 2025
概括
器官和芯片上的器官代表了体外癌症治疗评估的重大进展. 这些模型对于通过改善药物查和患者特异性治疗策略来推进精准医学至关重要.
科学领域:
- 生物医学工程 生物医学工程
- 在瘤学瘤学.
- 再生医学是一种再生医学.
背景情况:
- 在瘤学中,精准医学在很大程度上依赖于精确的体外模型来查药物.
- 目前的模型经常使用已建立的细胞系,限制了直接的临床适用性.
- 有机器人和芯片器官提供了更具生理相关性的替代品.
研究的目的:
- 审查各种体外模型在精密瘤学的应用.
- 突出患者衍生瘤器官和芯片上的瘤方面的进展.
- 讨论这些模型在个性化医学中的优点和局限性.
主要方法:
- 对体外癌症模型的现有文献的综述.
- 讨论二维细胞培养,来自患者的异种移植,瘤器官和芯片上的瘤.
- 分析最近的技术整合和临床试验的成功.
主要成果:
- 来自患者的瘤器官显示出高的施工成功率和临床试验适用性.
- 芯片上的瘤和芯片上的有机体显示了近期的重大进展.
- 与其他技术的整合增强了这些模型的功能.
结论:
- 器官和芯片上的瘤对于推进个性化癌症医学至关重要.
- 与传统方法相比,这些模型提供了更好的药物查和治疗评估.
- 需要进一步开发,以克服当前的限制,并最大限度地提高临床影响.
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