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瘤相关巨细胞的可向轴:一个MSF准确免疫疗法框架

Zhenting Lu¹, Midie Xu², Junzhe Tang¹

¹Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.

Biochimica et biophysica acta. Reviews on cancer

|September 25, 2025

概括

与瘤相关的巨细胞 (TAMs) 在癌症中起着双重作用. 了解它们的代谢重编程和相互作用是开发精确疗法的关键,这些疗法可以增强抗瘤免疫力并克服耐药性.

科学领域:

免疫学免疫学免疫学
癌症生物学癌症生物学
代谢过程中的代谢.

背景情况:

瘤相关巨细胞 (TAMs) 是瘤微环境的关键调节者.
TAMs表现出取决于背景的角色,通过复杂的机制影响癌症的进展.

研究的目的:

审查控制TAM两极分化和代谢重编程的机制.
探索TAMs,瘤细胞和树皮细胞之间的交叉声.
总结针对TAM用于癌症治疗的治疗策略.

主要方法:

文献综述综合了当前关于TAM两极化,新陈代谢和功能的知识.
介绍一个代谢-空间-功能轴框架.
免疫代谢与单细胞和空间分析数据的整合.

主要成果:

TAM极化是由分子和代谢电路塑造的,通常导致免疫抑制.
代谢重编程显著影响TAM表型和功能.
提出了一个新的框架,即代谢空间功能轴,以组织TAM异质性.

结论:

针对TAM代谢和血统途径提供了有前途的治疗策略.
代谢 - 空间 - 功能轴促进生物标志物引导的治疗组合.
重编程或限制TAMs的精确方法可以增强抗瘤免疫力并克服抗药性.

关键词:

免疫逃避是免疫逃避的一种方式.巨细胞的两极分化巨细胞-流体相互作用代谢重编程是一种代谢重编程.代谢-空间-功能 (MSF) 轴精确免疫疗法精确免疫疗法单细胞RNA测序的一个细胞.瘤微环境是一个微环境.与瘤相关的巨细胞.

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