在患有正常压力玻璃眼和夜间血压下降的患者中,快速的中央视野进展
Jimin Park1, Woo Keun Song1, Jooyoung Yoon1
1From the Department of Ophthalmology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
American journal of ophthalmology
|September 25, 2025
概括
过度浸泡的正常张力玻璃眼 (NTG) 患者经历了更快的视野 (VF) 进展. 显著的夜间血压 (BP) 下降是NTG患者快速VF损失的危险因素.
科学领域:
- 眼科医生 眼科 眼科
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 正常张力玻璃眼 (NTG) 具有视神经损伤和视野 (VF) 损失的特征,而眼内压力没有升高.
- 夜间血压 (BP) 浸泡模式,包括非浸泡,浸泡和过度浸泡,与各种心血管和脑血管疾病有关.
- 了解影响NTG快速VF进展的因素对于及时干预和预防视力损伤至关重要.
研究的目的:
- 调查夜间血压下降模式与早期至中度NTG阶段的患者中中心VF进展率之间的关联.
- 为了确定特定的BP浸泡类别是否预测加速的中央VF损失.
- 确定夜间血压下降是否是NTG中快速中央VF进展的风险因素.
主要方法:
- 一项前性队列研究,涉及199名未经治疗的NTG患者.
- 24小时的门诊血压监测 (ABPM) 和至少2年的随访.
- 根据夜间血压下降,将患者分为非浸入者,浸入者和过度浸入者;使用线性混合模型比较中央VF进展率;逻辑回归以确定快速VF进展的风险因素 (定义为MTD10下降<-0.5dB/年).
主要成果:
- 过度浸泡的人与非浸泡者 (-0.23dB/年) 和浸泡者 (-0.27dB/年) 相比,中心VF进展的速度明显更快 (-0.53dB/年) (P = .007).
- 快速的中央VF进展的患病率在过度浸泡者 (60.0%) 与非浸泡者 (19.8%) 和浸泡者 (23.5%) (P <.001) 中显著更高.
- 较高的夜间平均动脉压 (MAP) 降低的百分比是快速中心VF进展的重要危险因素 (OR:1.062,P <.05).
结论:
- 被归类为过度浸泡的NTG患者表现出明显加速的中央VF进展.
- 超过50%的过度浸泡者经历了快速的中央VF进展,突出了监测的关键子组.
- 夜间MAP下降的百分比是早期至中度NTG中快速中央VF进展的重要风险因素,强调需要密切监测这些患者的中央VF.
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