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功能网络连接偏差与跨诊断症状相关:大脑连接链接到跨诊断症状

Josina D Kist¹, Charlotte Fraza², Hannah S Savage³

¹Department of Psychiatry, Radboud University Medical Center, Nijmegen, the Netherlands; Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands; Department of Clinical Genetics, Erasmus Medical Centre, Rotterdam, the Netherlands.

Biological psychiatry. Cognitive neuroscience and neuroimaging

|September 25, 2025

概括

与对照人群相比,规范建模揭示了精神病患者脑功能连接的明显偏差. 这些神经偏差与跨诊断症状概况显著相关,突出显示了共享的神经生物学机制.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
计算精神病学是一种计算精神病学.

背景情况:

精神病患者群体表现出显著的并发症和异质性.
越来越多地使用跨诊断方法来了解大脑表型变异性.
规范模型提供了一个框架来评估个人的大脑功能偏差.

研究的目的:

通过规范建模来探索大脑表型关联.
为了计算个人的大脑功能偏差得分.
为了将这些分数与自然主义患者样本中的精神病理水平联系起来.

主要方法:

应用了规范建模来估计309名参与者 (患者和对照) 的大脑功能连接偏差.
通过稀疏的正规相关性分析,检查了神经偏差得分和精神病理学之间的关联.
包括传统的诊断类别,跨诊断症状概况和认知措施.

主要成果:

成功估计了规范模型,在患者和对照中确定了更极端的神经偏差得分.
发现神经偏差得分和跨诊断症状概况之间存在显著的关联 (R2 = 2.56%,p = .021).
与研究领域标准 (RDoC) 领域一致的偏差:负价值,认知,兴奋/抑制和社会系统.

结论:

在异质患者样本中,规范建模有效检测到功能性大脑连接差异.
像RDoC这样的跨诊断方法在识别共享的神经生物学机制方面比传统方法更准确.

关键词:

认知功能认知功能计算精神病学是一种计算精神病学.规范性建模规范性建模研究领域标准研究领域标准.休息状态功能成像功能成像跨诊断精神病学是一种精神病学.

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