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远红外疗法通过增强内皮功能和通过细胞保护途径降低动脉硬性来改善血管功能

Hala Bagabir¹, Omar A Mohammad², Chim C Lang²

¹Department of Physiology, Faculty of Medicine, King Abdulaziz University, Rabigh, Saudi Arabia; Neuroscience and Geroscience Research Unit, King Fahd Medical Research Centre, King Abdulaziz University, Jeddah, Saudi Arabia.

Free radical biology & medicine

|September 25, 2025

概括

远红外辐射 (FIR) 疗法通过增强内皮功能和减少动脉硬性,显著改善血管功能. 这种非侵入性方法激活了细胞保护性通路,为预防心血管疾病提供了潜在的潜力.

科学领域:

心血管研究研究心血管研究
医学物理医学物理
生物医学工程生物医学工程

背景情况:

远红外辐射 (FIR) 在心血管健康方面被认为具有治疗潜力.
FIR疗法可以增强内皮功能并减少动脉硬性,这是心血管完整性的关键指标.
这项研究调查了FIR血管效应的机制,重点关注基因表达和血管反应.

研究的目的:

研究局部FIR辐射对血管功能的影响,特别是健康受试者的内皮功能和动脉硬性.
检查FIR对氧化还原相关基因表达和血管反应的影响.
测试FIR通过抗氧化和抗炎机制改善血管功能,部分通过细胞保护基因上调调节的假设.

主要方法:

一个单盲试点研究,涉及50名健康参与者.
治疗包括FIR辐射,热或安慰剂,应用于背部上部.
通过激光多普勒成像评估血管功能与离子泳 (内皮功能) 和SphygmoCor (动脉硬性).
对外围血液单核细胞 (PBMCs) 的基因表达分析专注于与氧化还原相关的细胞保护基因和氧化合成酶 (NOS).

主要成果:

在健康个体中,FIR辐射显著增强了内皮功能,并减少了动脉硬.
在FIR暴露后,基因表达分析显示了细胞保护基因的上调,包括NOS3,TXNRD1和HSP70.
这些发现支持了FIR对血管益处的拟议机制.

结论:

FIR辐射有效地改善了血管功能,增强了内皮功能,降低了动脉硬度.
这些好处很可能是由细胞保护性通路的激活介导的.
FIR疗法为支持心血管健康和潜在预防心血管疾病提供了一个有希望的非侵入性策略.

关键词:

动脉硬性动脉硬性细胞保护细胞保护脑内皮功能脑内皮功能在FIRIR FIR中.血管功能血管功能

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