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Updated: Jan 16, 2026

Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes
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在KCNQ2-DEE的hiPSC模型中,KV7.2通道功能障碍会延迟神经元的成熟,并破坏早期网络的发展

Filip Rosa1, Stephan Theiss2, Susanne Krepp1

  • 1Dept. of Neurology and Epileptology, Hertie Center for Neurology & Hertie Institute for Clinical Brain Research, University and University Hospital Tübingen, Tübingen, Germany.

Neurobiology of disease
|September 25, 2025
PubMed
概括

KCNQ2发育性和性脑病变 (KCNQ-DEE) 源于影响M电流的KCNQ2基因变异. 这种干扰会延迟神经元发育,因为它会影响基本的功能性质,而不仅仅是过度兴奋.

关键词:
发育性和性脑病变,发育性和性脑病变.发育的振荡发展的振荡.人类iPSC模型KCNQ2 的时间.在M电流下,电流为M.

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