暴露于金属,生物衰老和代谢综合征:探索关联和调解效应
Xu Han1, Ziquan Lv2, Mei'an He3
1School of Public Health, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong, China; Department of Occupational and Environmental Health and Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
和等必需金属可能通过减缓生物衰老来降低代谢综合征 (MetS) 风险. 这项研究突出了金属在预防衰老和MetS中的作用.
科学领域:
- 环境健康 环境健康
- 代谢障碍 代谢障碍 代谢障碍
- 衰老的研究研究.
背景情况:
- 金属不平衡与代谢综合征 (MetS) 的进展有关,但机制尚不清楚.
- 衰老和环境暴露是已知的加快衰老的因素,可能影响慢性疾病.
- 生物年龄 (BA) 提供了一个关于衰老及其与疾病风险的关系的新视角.
研究的目的:
- 调查生物年龄 (BA) 在金属暴露和MetS风险之间的关系中扮演的调解角色.
- 探索基本金属如何通过生物衰老途径影响MetS.
- 通过影响生物衰老,识别可能减轻MetS风险的特定金属.
主要方法:
- 这是一项针对1,504名参与者的横截面研究.
- 使用克莱梅拉和杜巴尔方法 (KDM) 和马哈拉诺比斯距离计算的生物年龄指数 (BAI).
- 使用多变量回归和调解分析对七种血金属 (,,铜,,,,,) 的分析及其与BAI和MetS风险的关联.
主要成果:
- ,和与MetS风险和生物衰老指数有显著的负面关系 (p趋势<0.05).
- 生物衰老指数与MetS风险积极相关 (P<.001).
- 调解分析显示,BAI分别占和与MetS风险负面关联的19.15%和13.23%.
结论:
- 基本金属可以通过减缓生物衰老来降低MetS风险.
- 这项研究强调了必需金属在预防衰老和代谢综合征方面的重要性.
- 准金属稳态可能是管理与衰老相关的代谢障碍的新策略.
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