在瘤和心血管疾病的发展中,胆固醇和LDL吸收途径受损
Àngels Solanelles Curco1, Eduardo Garcia2, Anna Polishchuk1
1Institute of Biomedical Research of Barcelona (IIBB)-Spanish National Research Council (CSIC), Barcelona, Spain; Institut de Recerca Sant Pau (IR SANT PAU), Barcelona 08041, Spain.
Seminars in cancer biology
|September 25, 2025
概括
饮食中的脂质,特别是低密度脂蛋白 (LDL),在心血管疾病和癌症中至关重要. 它们的保留和失调的摄取扰乱了细胞脂质代谢和器官通信,推动了疾病的进展.
科学领域:
- 生物化学 生化学
- 细胞生物学 细胞生物学
- 病理学 病理学 病理学
背景情况:
- 饮食中的脂质会影响细胞过程,这些过程对心血管疾病和癌症至关重要.
- 脂蛋白受体介导参与瘤生长和血管改造的信号通路.
- 低密度脂蛋白 (LDL) 在细胞外基质 (ECM) 中的保留是动脉样硬化和癌症的关键事件.
研究的目的:
- 阐明饮食脂质和脂蛋白代谢在心血管疾病和癌症中的作用.
- 了解LDL的保留和吸收如何影响细胞内脂质积累和器官功能.
- 要突出脂肪滴 (LDs) 和线粒体功能障碍在疾病发病过程中的联系.
主要方法:
- 关于脂质代谢,脂蛋白受体和ECM蛋白质糖的现有文献的综述.
- 通过脂蛋白相互作用激活的细胞信号通路的分析.
- 在LD和线粒体中改变脂质和蛋白质含量的生物物理和功能后果的检查.
主要成果:
- 在ECM中LDL的保留促进了脂蛋白的修饰,促进疾病.
- 调节不良的修饰性脂蛋白的摄取导致LDs中过度的脂质积累.
- 脂质介质破坏了LD生物发生,线粒体功能和LD-线粒体相互作用.
- 功能障碍的LD-线粒体通信有助于代谢障碍和疾病进展.
结论:
- 饮食中的脂质和LDL新陈代谢对心血管疾病和癌症的发病起作用至关重要.
- 由脂质失调驱动的脂质滴和线粒体之间的改变相互作用在这些疾病中至关重要.
- 针对这些与脂质相关的机制可能为动脉样硬化和癌症提供新的治疗策略.
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