一项试点研究调查了吸烟对口腔微生物群中的口腔酸盐降低细菌的影响
Tomas L Nicholas1, Raul Bescos2, Amazon Doble1
1University of Plymouth, Peninsula Dental School, Plymouth PL48AA, UK.
Journal of dentistry
|September 25, 2025
概括
吸烟显著改变了口腔微生物组,降低了口腔酸盐降低细菌 (ONRB) 的活性和唾液酸盐水平. 这种转变可能会增加口腔和心血管疾病的风险.
科学领域:
- 微生物学 微生物学
- 口腔健康 口腔健康
- 心血管健康 心血管健康
背景情况:
- 口腔微生物组在维持口腔和全身健康方面发挥着至关重要的作用.
- 减少酸盐的细菌 (ONRB) 是氧化通路的关键参与者,影响血压和口腔健康.
- 吸烟是各种疾病的主要风险因素,但它对ONRB的具体影响尚未完全理解.
研究的目的:
- 在体内和体外研究香烟烟雾对口腔酸盐降低细菌 (ONRB) 的活性和丰度的影响.
- 分析与吸烟和ONRB活动相关的唾液生物标志物.
- 为了确定香烟烟雾对特定口腔细菌的酸盐降低能力的影响.
主要方法:
- 一项观察性研究比较了11名吸烟者和31名非吸烟者.
- 收集唾液和酸盐冲洗样本用于生物标志物分析和ONRB评估.
- 在体外实验中,四种Rothia物种暴露在香烟烟雾中,以评估酸盐降低活性.
主要成果:
- 在吸烟者和非吸烟者之间观察到口腔微生物组β多样性的显著差异 (P = 0.0063).
- 吸烟者唾液中酸盐含量较低 (P = 0.034),pH值降低 (P = 0.058),酸含量增加 (P = 0.018).
- 在实验室中,香烟烟雾抑制了Rothia物种的酸盐降低活性 (P = 0.0046).
结论:
- 吸烟减少了唾液中酸盐,并以物种依赖的方式改变了ONRB的丰度.
- 在实验室中观察到Rothia物种对酸盐降低活性的抑制作用.
- 观察到的口腔微生物组和酸盐减少的变化可能导致口腔和心血管疾病风险增加.
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