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在不复杂的犬类肌肉测量中,安慰剂与术后抗菌治疗无劣 - - 一个双盲随机对照试验

Anna Ylhäinen¹, Merja Rantala¹, Katariina Thomson²

¹Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, P.O. Box 57 (Viikintie 49), Helsinki FI-00014, Finland.

Veterinary journal (London, England : 1997)

|September 25, 2025

概括

术后的抗生素通常是不必要的不复杂的犬类皮奥美特外科手术. 一项研究发现,单次术前剂量硫二甲-三甲在预防手术部位感染方面与五天疗程同样有效.

科学领域:

兽医外科兽医外科兽医外科
传染性疾病传染性疾病
药理学药理学是指药理学的学科.

背景情况:

术后的抗微生物治疗在狗的皮奥美特拉手术后是常见的,但证据表明它在无并发病例中的必要性是有限的.
关于抗菌素耐药性的担忧需要重新评估常规术后抗生素的使用.
这项研究解决了关于在治疗犬类皮奥美特时使用外科手术期间抗生素的基于证据的指导方针的需求.

研究的目的:

为了评估安慰剂的非劣势性,与硫法迪亚-trimethoprim为期五天的疗程相比,用于预防在狗体外科手术后的术后感染.
为了确定单一的硫黄素-三甲的周术剂量是否足以预防这种手术患者群体的感染.

主要方法:

一个随机的,双盲的,安慰剂控制的,非劣势性试验,涉及152名客户拥有的狗接受皮奥美特拉手术.
所有的狗都接受了外科手术期间的硫黄素-三甲胺预防.
狗被随机分配给接受安慰剂或五天的口服硫法迪亚-trimethoprim疗程.

主要成果:

在30天内,手术部位感染 (SSI) 的发生率在安慰剂组为2.7%,在硫黄diazine-trimethoprim组为7.8%.
临床尿路感染 (UTI) 在12天内发生率在安慰剂组为0%,在硫法迪亚-三甲组为3.9% (不支持劣势).
在治疗意图和每条协议分析中,结果一致.

结论:

单次术前剂量硫二氧化三甲似乎足以预防皮奥外科手术的狗的术后感染.
对于没有并发症的病例,可能不需要常规延长的术后抗微生物治疗,这可能会降低抗微生物耐药性.
这些研究结果支持修订当前关于在狗体外科手术中术后抗生素使用的做法.

关键词:

抗微生物治疗的治疗方法狗的气度测量仪随机控制的非劣势性试验.手术部位感染的感染.尿路感染尿路感染

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