腕脉冲波速对扩张功能障碍进展的影响:一个队列研究
Seung Hun Lee1, Ki Hong Choi2, Sung Won Cho3
1Department of Cardiology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea.
Revista espanola de cardiologia (English ed.)
|September 25, 2025
概括
通过腕脉冲波速度 (baPWV) 测量动脉硬度升高,与扩张性功能障碍 (DD) 的更高的患病率和更快的进展有关. 较高的baPWV也会增加一般人群全因死亡的风险.
科学领域:
- 心脏病学 心脏病学
- 血管生物学 血管生物学
- 预防医学 预防医学
背景情况:
- 动脉硬是已知的心血管事件的预测因素.
- 左心室透静功能障碍 (DD) 与动脉硬有关,可能导致心力衰竭.
- 在一般人群中对动脉硬和DD的纵向数据有限.
研究的目的:
- 为了研究动脉硬性 (通过脚脉冲波速率,baPWV进行评估) 与扩张性功能障碍 (DD) 的患病率和进展之间的联系.
- 评估长期结果,包括因任何原因的死亡率,与大规模社区群体中不同水平的baPWV相关.
主要方法:
- 对16,476名成年人 (≥18岁) 的回顾性队列研究,基线心声图和baPWV测量.
- 参与者分为正常,边缘和高的baPWV组.
- 多变量回归分析以评估与DD进展和所有原因死亡率的关联.
主要成果:
- 与正常人相比,边界 (PR, 1.73) 和高 (PR, 3.25) baPWV组中确定的DD的流行率更高.
- 边界和升高的baPWV与左心室填充压力 (E/e') 在4年内更快地增加有关.
- 升高的baPWV独立与发生DD的风险增加有关 (HR, 2.61) 和所有原因的死亡率 (HR, 3.91).
结论:
- 边界和升高的baPWV显著与更高的DD流行率和更快的进展有关.
- baPWV是DD病理生理学的重要因素.
- baPWV作为一种有用的非侵入性工具,用于一般人群中心血管风险分层.
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