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和多醇基物质和婴儿的肠道微生物群:一个范围审查

Ida Asta Olsen¹, Merete Eggesbø², Urvish Trivedi³

¹National Institute of Public Health, University of Southern Denmark, 1455, Copenhagen, Denmark.

Environmental research

|September 25, 2025

概括

和多基基物质 (PFAS) 可能会影响婴儿的肠道微生物. 本综述强调了PFAS暴露与婴儿肠道微生物组合的改变之间的潜在联系,强调需要进一步研究.

科学领域:

环境健康环境健康
微生物学微生物学
儿科儿科儿科

背景情况:

和多基基物质 (PFAS) 是持久性环境污染物,与不良健康结果有关.
婴儿肠道微生物群的发展对健康至关重要,新出现的证据表明,它可能受到PFAS暴露的影响.

研究的目的:

系统地审查调查PFAS暴露与婴儿肠道微生物群组成之间的关联的流行病学研究.
综合当前关于PFAS如何影响婴儿肠道微生物组发展的证据.

主要方法:

在PubMed.com进行了系统的文献搜索.
分析了7项符合纳入标准的流行病学研究.
微生物群组成使用16S rRNA测序或猎枪元基因组学来评估.

主要成果:

暴露于PFAS,特别是PFOS和PFOA,与改变肠道微生物群的α和β多样性有关.
特定的细菌种群表现出丰富的变化,其中一些增加 (例如,Enterococcus) 和其他减少 (例如,Faecalibacterium,Phocaeicola vulgatus).
据报道,由于暴露于PFAS,功能途径,包括胆酸代谢,都被改变了.

结论:

目前的证据表明,PFAS暴露对婴儿肠道微生物群组成的潜在影响.
跨研究的不一致性可能源于设计,共变量和方法的变化.
需要进行更大规模的纵向研究来证实这些关联并了解长期影响.

关键词:

阿尔法多样性的多样性污染物污染物污染物环保环境环境环境这是一个很棒的体验,Gut Gut Gut Gut.婴儿婴儿婴儿微生物群中的微生物群在PFAS中,有很多方法.

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