在先进的血液和固体瘤中,在家庭进行红细胞输血的有效性和安全性
Naohiro Miyashita1, Kota Ohashi2, Masahiro Onozawa3
1Department of Hematology and Palliative Medicine (N.M.), HOME CARE CLINIC N-CONCEPT, Sapporo, Japan; NPO Hemato-Homecare Network (N.M., K.O.), Tokyo, Japan.
Journal of pain and symptom management
|September 25, 2025
概括
家庭红细胞输血 (RBC-TF) 为绝症患者提供安全有效的息选择,特别是那些患有血液性恶性瘤的患者. 谨慎的患者选择是关键,特别是对于那些患有晚期缓冲症的人来说.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 抚慰性护理是一种缓解性护理.
背景情况:
- 家庭红细胞输血 (RBC-TF) 是对患有贫血相关症状的绝症患者的潜在息治疗,这些患者难以进入医疗机构.
- 基于家庭的RBC-TF的临床实用性和安全性需要进一步调查.
研究的目的:
- 评估在患有血液性恶性瘤 (HM) 和固体瘤 (ST) 的绝症患者的家庭RBC-TF的有效性和安全性.
- 评估与家庭RBC-TF相关的程序特征和症状缓解.
主要方法:
- 一项回顾性研究分析了77名末期HM或ST患者,他们在2020年7月至2025年2月期间接受了家庭RBC-TF.
- 通过缓解症状来评估有效性,通过不良事件 (AE) 来评估安全性,并分析了癌症缓解症生物标志物.
- 遵循标准化方案,包括预先治疗和使用白血病减少,放射性红细胞.
主要成果:
- 1664个单位的红细胞被输血. 与ST患者相比,HM患者的疲劳 (94.1%与53.8%) 和食欲丧失 (55.0%与6.7%) 的症状改善显著更好.
- 没有观察到严重的副作用;轻度过敏反应发生在0.29%的输血中.
- 在ST患者中,表现出更严重的缓解症标志物,包括较低的白蛋白和较高的CRP水平.
结论:
- 基于家庭的RBC-TF是对精心挑选的绝症患者的可行和安全的息干预,特别是那些患有HM的患者.
- 标准化输血协议似乎可以提高安全性.
- 患者的选择至关重要,特别是对于那些患有晚期缓冲症的人来说,他们可能会经历有限的益处.
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