肥胖与慢性移植对宿主疾病的关联
Valentina Ardila1, Lynn Onstad2, Paul Carpenter3
1Hematology and Oncology Training Program, Sylvester Comprehensive Cancer Center | University of Miami | Jackson Health System, Miami, Florida.
Transplantation and cellular therapy
|September 25, 2025
概括
肥胖与慢性移植对宿主疾病 (GVHD) 患者的生活质量恶化有关. 然而,肥胖并没有显著影响该研究群体的GVHD严重程度,治疗反应或生存结果.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 肥胖是一个日益关注的问题,与炎症和较差的疾病结果有关.
- 临床前数据表明,肥胖会对移植与宿主疾病 (GVHD) 有负面影响.
- 关于肥胖对全原造血细胞移植 (HCT) 和慢性GVHD的影响的临床数据有限且相互矛盾.
研究的目的:
- 调查肥胖与器官参与,严重程度和慢性GVHD治疗反应的关联.
- 评估肥胖对慢性GVHD患者的生存结果 (整体存活率,非复发性死亡率,无故障存活率) 和生活质量的影响.
主要方法:
- 从2007年至2019年,对487名新诊断的慢性GVHD患者进行了回顾性分析.
- 肥胖被定义为身体质量指数 (BMI) ≥30.
- 肥胖和非肥胖患者之间慢性GVHD特征,治疗反应,存活率和生活质量的比较.
主要成果:
- 114名 (23.4%) 患者被归类为肥胖 (BMI ≥30).
- 肥胖与糖尿病相关,但与GVHD等级,器官参与或治疗反应的差异无关.
- 慢性肺GVHD在肥胖患者中更频繁 (P = .047),但生存结果 (OS,NRM,FFS) 并没有显著差异.
- 肥胖患者在入学时和入学后6个月报告了更大的症状负担和更差的生活质量.
结论:
- 肥胖与慢性GVHD的异性HCT接受者生活质量下降有关.
- 肥胖并没有显著影响慢性GVHD表型,治疗响应度或生存结果.
- 使用详细的身体成分测量方法进行进一步的研究是有必要的,以阐明肥胖在慢性GVHD中的作用.
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