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Updated: Jan 16, 2026

Identification of Inositol Phosphate or Phosphoinositide Interacting Proteins by Affinity Chromatography Coupled to Western Blot or Mass Spectrometry
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Published on: July 26, 2019

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不同HDAC复合物的抑制剂的有效性和选择性

Wiktoria A Pytel1,2, Urvashi Patel1,3, Joshua P Smalley1,3

  • 1Institute for Structural and Chemical Biology, University of Leicester, Leicester LE1 7RH, U.K.

Journal of the American Chemical Society
|September 25, 2025
PubMed
概括

基氨酸脱乙酶 (HDAC) 抑制剂表现出复合体依赖活性,而异醇酸盐显著改变功效. 评估HDAC抑制剂在它们的原生复合体内对于了解体内疗效至关重要.

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