空气污染物和乳腺癌风险:对美国五大潜在队列的并行分析
Alexandra J White1, Jaime E Hart1, Sabah M Quraishi1
1Alexandra J. White and Dale P. Sandler are with the Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC. Jaime E. Hart and Francine Laden are with the Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA. At the time of this work, Sabah M. Quraishi was with the Department of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Seattle, WA. Deborah B. Bookwalter is with Public Health and Epidemiology Practice, Westat, Rockville, MD. Marina R. Sweeney is with Social & Scientific Systems, a DLH Holdings Company, Durham, NC. Elizabeth W. Spalt and Joel D. Kaufman are with the Department of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Seattle. Michael S. Hendryx is with the Department of Environmental and Occupational Health, Indiana University School of Public Health, Bloomington. Veronica L. Irvin is with the College of Health, Oregon State University, Corvallis. Dorothy S. Lane is with the Department of Family, Population, and Preventive Medicine, Stony Brook University, Stony Brook, NY. Aladdin H. Shadyab is with the Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla. Shawnita Sealy-Jefferson is with the Division of Epidemiology, College of Public Health, The Ohio State University, Columbus. Marian L. Neuhouser is with the Division of Public Health Sciences, Fred Hutchinson Cancer Center and School of Public Health, University of Washington, Seattle. Eric A. Whitsel is with the Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill.
室外空气污染,包括二氧化 (NO2),细颗粒物 (PM2.5) 和臭氧,与乳腺癌发病率的增加有关. 这项研究发现PM2.5和臭氧与雌激素受体阴性/孕激素受体阴性瘤之间的特定关联.
科学领域:
- 环境流行病学环境流行病学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 室外空气污染是对环境的重大暴露,具有潜在的健康影响.
- 以前的研究表明,空气污染物与各种癌症之间存在联系,但乳腺癌的证据需要进一步调查.
研究的目的:
- 调查住宅暴露于环境二氧化 (NO2),细颗粒物 (PM2.5) 和臭氧与美国乳腺癌发病率之间的联系.
- 通过不同乳腺癌亚型,特别是雌激素受体 (ER) /孕激素受体 (PR) 阳性和阴性瘤,以及按地理区域检查这些关联.
主要方法:
- 利用来自美国大型队列的数据:护士健康研究,妇女健康倡议和姐妹研究.
- 使用高分辨率的时空模型估计了个体级空气污染物度 (NO2,PM2.5,臭氧).
- 使用Cox比例危险回归和随机效应模型来估计危险比率 (HR) 和置信区间 (CI).
主要成果:
- 二氧化 (NO2) 暴露与整体乳腺癌发病率 (HR=1.03) 有积极关联.
- 细颗粒物 (PM2.5) 暴露与更高的ER-/PR-瘤发病率 (HR=1.14) 和中西部的整体发病率 (HR=1.15) 有关.
- 臭氧暴露与更高的ER-/PR-瘤发病率有关 (HR=1.10).
结论:
- 这项美国大规模研究证实了NO2暴露与乳腺癌发病率之间的关联.
- 在PM2.5和臭氧暴露以及ER-/PR-乳腺瘤的发病率之间发现了新的关联.
- 研究结果强调了空气质量在乳腺癌预防策略中的重要性.
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