Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

201
Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
201
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

144
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
144
Bioavailability Study Design: Single Versus Multiple Dose Studies01:11

Bioavailability Study Design: Single Versus Multiple Dose Studies

210
Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
210
Phase II Reactions: Methylation Reactions01:17

Phase II Reactions: Methylation Reactions

676
Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
676
Clinical Trials01:16

Clinical Trials

10.1K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
10.1K
Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

263
Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
263

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Vitamin D supplementation during pregnancy: Position statement of the Groupe de Recherche et d'Information sur les Osteoporoses.

Joint bone spine·2026
Same author

[Abdominal pain, fever and arthralgia in a 49-year-old woman].

La Revue de medecine interne·2026
Same author

Second interim analysis of the post-authorisation safety study (PASS) of burosumab in paediatric patients with X-linked hypophosphataemia.

European journal of endocrinology·2026
Same author

IgA Vasculitis with necrotizing arteritis: a multicenter retrospective study from the French Vasculitis Study Group and systematic review of the literature.

Autoimmunity·2026
Same author

Rare disease care pathways profile in France: leveraging hospital big data to characterize natural history in osteogenesis imperfecta.

JBMR plus·2026
Same author

Investigating synovial trace elements as diagnostic markers in acute septic arthritis: an exploratory study.

Clinical rheumatology·2026

相关实验视频

Updated: Jan 16, 2026

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

817

METHOFRACT,一种甲基酸骨质炎多中心队列研究.

François Robin1,2, Roba Ghossan3, Nadia Mehsen-Cetre4

  • 1Univ Rennes, INSERM, INRAE, CHU Rennes, UMR 1317 1341, Institut NuMeCan (Nutrition Metabolisms and Cancer), Rennes, France francois.robin@chu-rennes.fr.

RMD open
|September 25, 2025
PubMed
概括

甲三甲酸诱导的骨质疏松症 (MTX-IO) 骨折很少见,通常影响有RA或PSA的绝经后妇女. 停止使用甲状腺素显著改善骨折愈合和缓解疼痛.

关键词:
甲基甲酸二醇的使用方法骨质疏松症是一种骨质疏松症.疼痛 疼痛 疼痛 疼痛

更多相关视频

Assessment of Bone Fracture Healing Using Micro-Computed Tomography
12:04

Assessment of Bone Fracture Healing Using Micro-Computed Tomography

Published on: December 9, 2022

2.4K
Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
07:24

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

Published on: January 23, 2018

10.7K

相关实验视频

Last Updated: Jan 16, 2026

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

817
Assessment of Bone Fracture Healing Using Micro-Computed Tomography
12:04

Assessment of Bone Fracture Healing Using Micro-Computed Tomography

Published on: December 9, 2022

2.4K
Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
07:24

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

Published on: January 23, 2018

10.7K

科学领域:

  • 类风湿病学 类风湿病学
  • 整形外科 整形外科 整形外科
  • 药物监督 药物监督 药物监督

背景情况:

  • 甲基酸诱导的骨质病变 (MTX-IO) 是一种罕见的并发症,影响患有类风湿性关节炎 (RA) 或牛皮性关节炎 (PsA) 的患者.
  • 它通常呈现为下肢骨折,特别是在骨和脚部.
  • 了解受影响的人口和风险因素对于管理至关重要.

研究的目的:

  • 确定MTX-IO患者的人口和临床特征.
  • 描述骨折模式,并确定不良结果的风险因素.
  • 评估甲状腺素断药对临床结果的有效性.

主要方法:

  • 一项多中心的回顾性研究,涉及92名被诊断患有MTX-IO的患者.
  • 数据收集包括临床表现,成像 (MRI,骨光学),骨矿物质密度和生物化学标记.
  • 分析重点是骨折特征,患者人口统计和治疗结果.

主要成果:

  • 该研究主要包括患有血清阳性RA的绝经后妇女 (92名患者,2012-2024年).
  • 常见的骨折部位是骨转移 (88%) 和脚骨 (49%),频繁出现多重和复发性骨折.
  • 在诊断时,骨质疏松症在56%的患者中存在.
  • 停止使用甲状腺素导致明显改善骨折愈合和缓解疼痛 (91%对29%,p<0.001).

结论:

  • MTX-IO是一种显著的疾病,特别是在患有RA或PsA的绝经后妇女中.
  • 建议使用MRI或骨光学提前诊断.
  • 停止治疗甲状腺素是改善结果和预防进一步骨折的关键.