对高脂肪饮食的时间限制影响体重增加,饮食模式和食物偏好
Payam A Fathi1, Michelle B Bales1, Pranav Sathu1
1Department of Molecular Physiology & Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Obesity (Silver Spring, Md.)
|September 25, 2025
概括
在光周期期间给小鼠提供高脂肪饮食 (HFD) 增加了体重增加和脂肪质量. 相反,暗循环HFD访问在小鼠中减少了脂肪和增强了食偏好.
科学领域:
- 营养科学 营养科学
- 代谢研究研究 代谢研究
- 时间生物学 时间生物学
背景情况:
- 饮食时间影响代谢健康.
- 高脂肪饮食 (HFD) 可以导致不良的代谢结果.
- 循环节律在调节食行为和新陈代谢方面发挥着重要作用.
研究的目的:
- 为了研究高脂肪饮食 (HFD) 限制小鼠进入光或黑暗周期的代谢效应.
- 评估在定时HFD暴露下体重,身体组成,食行为和代谢参数的变化.
- 为了将这些结果与自由选择权 (ad libitum) 进行比较.
主要方法:
- 在代谢室中使用了雄性C57BL/6J小鼠.
- 小鼠可以接触到HFD或,HFD仅限于明暗周期.
- 测量包括食物摄入量,饮食模式,能量消耗,活动,基质氧化,体重和4周的组成.
主要成果:
- 在光周期期间访问HFD的小鼠表现出更大的体重和脂肪质量增加.
- 光周期HFD接入导致HFD偏好增加,白天HFD餐更大,更频繁.
- 黑暗周期HFD访问促进了食偏好和更大,更频繁的白天食,尽管摄入的热量相当.
结论:
- 限制HFD进入光循环会导致类似于ad libitum HFD消费的有害代谢结果.
- 在黑暗周期中访问HFD可以减轻体重增加和脂肪.
- 暗循环HFD访问与偏爱食而不是HFD有关.
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