慢性胰腺炎中肉类的患病率和影响:系统性审查和元分析
Mohamed Abdulla Ghuloom Abdulla Bucheeri1, Kareem Khalaf1, Huaqi Li1
1Division of Gastroenterology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
概括
大约41%的慢性胰腺炎患者患有肉症,这种疾病与较低的BMI有关. 这凸显了对 Sarcopenia 进行标准化查和进一步研究的需要.
科学领域:
- 胃肠病学 胃肠病学
- 内部医学 内部医学
- 营养科学 营养科学
背景情况:
- 慢性胰腺炎 (CP) 是一种渐进的炎症状况,导致胰腺不可逆转的损伤,并导致外分泌和内分泌功能不充分.
- 系统性影响,如营养不良,虚弱和麻症显著导致CP患者的发病率和死亡率.
- 目前针对CP的干预措施主要针对形态问题,而不是营养不良和肉类的系统后果.
研究的目的:
- 系统地审查和元分析慢性胰腺炎患者的萨尔科佩尼亚患病率.
- 评估 CP 患者的肉类和身体质量指数 (BMI) 之间的关联.
主要方法:
- 在MEDLINE和Embase数据库上进行了系统的文献搜索,遵循PRISMA指南.
- 包含的研究报告了CP患者的萨尔科佩尼亚患病率,使用各种方法诊断.
- 进行了一项随机效应聚合比例元分析,以确定萨科佩尼亚的总体患病率.
主要成果:
- 分析了15项涉及1365名CP患者的研究.
- 在CP患者中,肉症的综合患病率为40.9% (95%CI:28.4%-58.9%).
- 与非sarcopenic患者相比,sarcopenic CP患者的平均BMI显著低于非sarcopenic患者 (平均差异: -2.62,p < 0.01).
结论:
- 在慢性胰腺炎患者中,很大一部分 (约41%) 患有肉类.
- 脑膜炎患者的肉类似乎与较低的身体质量指数有关.
- 建议进行进一步的研究,以标准化在CP中 Sarcopenia的查和评估,并调查其对患者结局的影响.
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