吸入抗生素的生物化学特征与耐受性有关
Manuel Vélez-Díaz-Pallarés1, María Ángeles Parro-Martín1, Hilario Martínez-Barros2
1Servicio de Farmacia, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain.
概括
吸入性抗生素的制备缺乏标准化,许多静脉注射配方未经标签使用. 一些稀释物表现出不安全的生物化学参数,可能会危及患者的安全和治疗的有效性.
科学领域:
- 肺部医学 肺部医学
- 药理学 药理学是指药理学的学科.
- 临床药房 临床药房
背景情况:
- 吸入的抗生素对于诸如囊性纤维化 (CF) 和呼吸器相关的肺炎等呼吸道疾病至关重要.
- 制备方法的标准化,包括稀释和复制,往往缺乏吸入抗生素配方.
- 一些被批准用于静脉注射的抗生素需要特殊的方案来吸入.
研究的目的:
- 评估科学文献中描述的吸入抗生素溶液的制备方法和生物化学参数的频率.
- 在临床实践中调查吸入抗生素使用的流行情况.
- 评估吸入抗生素溶液的生物化学特性,以评估患者的耐受性.
主要方法:
- 进行了MEDLINE的文献审查,以确定吸入抗生素稀释的研究.
- 进行了一项全国性的调查,以确定当前的医院实践,以吸入抗生素稀释.
- 进行了生物化学分析 (pH,度,离子度) 并记录了辅助剂.
主要成果:
- 在文献中确定了737种吸入抗生素混合物,其中476种非标准化,只有190种具有精确的稀释说明.
- 一项全国性调查显示,静脉注射抗生素制剂的广泛使用用于吸入 (64.7%的中心).
- 实验室分析显示,一些稀释品超出了可接受的耐受性范围,特别是复制干粉和稀释静脉注射溶液.
结论:
- 关于吸入抗生素制剂和生物化学性质的科学文献有限.
- 在标签之外使用静脉注射的吸入配方是常见的.
- 一些吸入抗生素稀释物具有可能危及治疗安全性和有效性的生化参数.
关键词:
抗菌剂是一种抗菌剂.抗菌剂是一种抗菌剂.支气管切除症是一种支气管切除症.支气管切除亚洲人的情况.医院医院的药房在标签之外使用药房服务,医院医院服务.安全的安全的安全的安全的安全.安全性 安全性 安全性 安全性.耐受性是可以承受的.耐受性 耐受性在指示之外的使用.更多相关视频
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