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Updated: Jan 16, 2026

In vitro Organoid Culture of Primary Mouse Colon Tumors
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通过调节TCF3/MCM2/5轴的DNA复制,TRIM21促进结直肠癌的发展

Xintian Zhang1, Han Yao1, Yichao Hou1

  • 1Shanghai Key Laboratory of Gut Microecology and Associated Major Diseases Research, Digestive Disease Research and Clinical Translation Center, Department of Gastroenterology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhi Zao Ju Road, 200011, Shanghai, China.

Cell death discovery
|September 25, 2025
PubMed
概括

含有21 (TRIM21) 的三部分基因通过调节DNA复制促进结直肠癌 (CRC) 细胞生长. 抑制TRIM21可以增强CRC的化学敏感性,为这种癌症提供潜在的治疗策略.

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