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Ugo Lomoio1, Valentina Carbonari1, Federico Manuel Giorgi2

  • 1Department of Surgical and Medical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.

NPJ systems biology and applications
|September 25, 2025
PubMed
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转氨基粉症 (ATTR) 治疗方法因遗传突变而异. 计算方法揭示了TTR蛋白变体如何影响药物结合,指导个性化稳定剂的开发,以获得更好的疗效.

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...