相关实验视频
Updated: Jan 16, 2026

08:25
Analysis of Coronary Vessels in Cleared Embryonic Hearts
Published on: December 7, 2016
8.6K
在肠壁和介质体内由来自肠道的Esm1+内皮细胞形成动脉
Esther Bovay1, Kai Kruse2, Emma C Watson1
1Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, Münster, Germany.
Nature communications
|September 25, 2025
概括
在胚胎小鼠肠道中,表达内皮细胞特异分子1 (Esm1) 的特定内皮细胞组对于形成肠道和介质动脉至关重要. 这些细胞迁移和分化以建立重要的血管网络.
科学领域:
- 血管生物学 血管生物学
- 发育生物学是发展生物学.
- 有机体发生的细胞和分子机制.
背景情况:
- 动脉血液供应对于器官功能,生长和修复至关重要.
- 动脉形成或功能上的缺陷与各种人类疾病有关.
- 大多数器官中动脉发育的细胞起源和分子途径尚未得到充分理解.
研究的目的:
- 确定负责胚胎肠道动脉发育的特定细胞群.
- 阐明控制动脉内皮细胞与前体细胞分化的分子机制.
- 研究内皮细胞特异性分子1 (Esm1) 在动脉形成中的作用.
主要方法:
- 在胚胎小鼠模型中的遗传方法.
- 免疫组织化学用于识别细胞群和标记物.
- 单细胞RNA测序用于分析细胞分子概况.
- 调查对整蛋白β1,VEGF-C和VEGFR3信号传导的要求.
主要成果:
- 在肠内,表达Esm1 (Esm1+) 的内皮细胞的一个亚群被确定为动脉前体.
- 这些Esm1+细胞在肠壁和中肠血管结构中都对动脉内皮有贡献.
- Esm1+细胞表现出明显的分子特征,并具有动脉分化的能力.
- 由Esm1+细胞介导的动脉形成需要整体蛋白β1和通过VEGF-C/VEGFR3.3传递信号.
结论:
- 肠道Esm1+细胞是肠道和介质动脉发展的关键来源.
- 这些发现揭示了一种新的细胞机制,有助于外周器官的血管发育.
- 了解这些机制可以了解先天性血管异常和潜在的治疗点.
相关概念视频
Development of Blood Vessels
1.4K
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
1.4K
Mechanism of Angiogenesis
6.7K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
6.7K
Renewal of Intestinal Stem Cells
3.2K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
3.2K
Development of the Lymphatic System
2.0K
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
2.0K
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.6K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.6K
Regulation of Angiogenesis and Blood Supply
3.3K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.3K

