在骨再吸收过程中证明了内在的昼夜节律
Andrea L Darling1, Benita A Middleton2, Fatma Gossiel3
1Nutrition, Exercise, Chronobiology and Sleep, School of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK. ad0089@surrey.ac.uk.
Scientific reports
|September 25, 2025
概括
骨再吸收标志物显示出强大的昼夜节律,表明骨质细胞活动的强烈内部时钟调节. 然而,骨形成标记物显示了最小的昼夜节律,这表明对骨质母细胞的内部时钟控制有限.
科学领域:
- 时间生物学 时间生物学
- 骨的新陈代谢 骨的新陈代谢
- 内分泌学 在内分泌学.
背景情况:
- 已知骨循环中的每日节律,但它们作为内在的昼夜节律的起源仍然不清楚.
- 了解骨循环的昼夜调节对于代谢性骨病管理至关重要.
研究的目的:
- 调查骨周转的每日节律是否是内在产生的昼夜节律.
- 确定骨形成和再吸收的昼夜节律的性别特异性.
主要方法:
- 利用常规的常规协议来最大限度地减少对昼夜节律的外部影响.
- 在健康的成年人中,每2小时超过26小时,测量1型原蛋白N终端 (sPINP) 和1型原蛋白C终端端 (sCTX).
- 分析了 sinus 节律的数据,使用 cosine 和 cosine+线性模型,评估了 acrophase,幅度和统计学意义.
主要成果:
- 血清CTX (骨再吸收标志物) 在男性和女性表现出强大的昼夜节律,峰值时间相似,但女性的幅度较低.
- 血清sPINP (骨形成标记物) 显示,只有少数参与者 (36%的男性,1名女性) 具有统计学意义的昼夜节律.
- 总的来说,sCTX表现出明确的昼夜节律,而sPINP则没有,表明骨周转的昼夜调节的性别特异性差异.
结论:
- 昼夜时钟通过骨质细胞强有力的调节骨再吸收.
- 骨质母细胞对骨形成的生理时钟调节似乎是最小的.
- 这些发现突出了对骨重塑过程的差异性昼夜控制.
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