整合转录基因和表观基因数据以确定妊娠糖尿病患者的潜在生物标志物
Tridip Mitra1, Dinesh Venkatesan Yadav2, Sajeetha Kumari R1
1Division of Medical Research, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Kattankulathur, 603203, Tamil Nadu, India.
Scientific reports
|September 25, 2025
概括
孕期糖尿病 (GDM) 研究确定了18个新型基因作为诊断和治疗点的潜在生物标志物. 这些发现为管理这种常见的妊娠障碍和改善母亲和胎儿健康结果提供了新的途径.
科学领域:
- 基因组学和分子生物学
- 生殖健康 生殖健康
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 孕期糖尿病 (GDM) 是怀孕期间普遍存在的代谢障碍.
- GDM对母亲和胎儿都带来了直接和长期的健康风险.
- 了解GDM的细胞和分子变化对于开发新的诊断和治疗策略至关重要.
研究的目的:
- 为了确定GDM的新型诊断生物标志物.
- 发现GDM管理的潜在治疗点.
- 为了描述GDM的分子景观.
主要方法:
- 对三个转录组数据集的分析,以识别差异表达基因 (DEGs).
- 基因本体学,KEGG通路和疾病本体学丰富分析.
- 甲基化和转录基因数据的整合,以及免疫细胞类型透和蛋白质-蛋白质相互作用分析.
主要成果:
- 在GDM患者中确定了449个上调和785个下调的DEG.
- 丰富分析显示了迁移,免疫和代谢途径的参与.
- 综合多种基因的数据,确定了11个候选基因和7个具有高诊断潜力的枢纽基因.
结论:
- 总共有18个基因被确定为潜在的新型诊断生物标记物和GDM的治疗点.
- 这些基因对于理解GDM病理生理学至关重要.
- 这些发现为改善GDM诊断和治疗铺平了道路.
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