在中国心力衰竭患者中,高灵敏度C反应蛋白和6个月全因死亡率
Ailing Zhu1, Jinfeng Zhang1, Shuanglin Zhou1
1Nanjing Meishan Hospital, Nanjing, 210041, People's Republic of China.
Scientific reports
|September 25, 2025
概括
高敏感性C反应蛋白 (hs-CRP) 的升高与中国心力衰竭患者的六个月死亡率增加有关. 这一发现支持使用hs-CRP用于心力衰竭管理中的风险分层.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 公共卫生 公共卫生
背景情况:
- 心力衰竭 (HF) 是全球疾病和死亡的主要原因.
- 高敏感性C反应蛋白 (hs-CRP) 是一种炎症标志物,在HF患者中升高,并与不良结果相关.
- 在中国高温肺炎患者中hs-CRP的预后价值需要进一步澄清.
研究的目的:
- 调查中国HF患者hs-CRP水平与六个月全因死亡率之间的关联.
- 通过多变量逻辑回归来评估hs-CRP的独立预后值.
- 探索hs-CRP与死亡风险之间的潜在非线性关系.
主要方法:
- 在2016年1月至2019年12月期间住院的941名高风患者的回顾性队列研究.
- 分析hs-CRP数据的对数转换和三级分层.
- 采用了多变量逻辑回归和受约束的立方线转换.
主要成果:
- 六个月所有原因的死亡率为3.08%.
- 升高的hs-CRP度在调整混杂因子后显著与增加的死亡风险相关 (OR=2.073,p=0.047).
- hs-CRP显示出对死亡率的预测值 (AUC=0.66),最佳截止值为1.64;没有检测到非线性关联.
结论:
- 在中国HF患者的hs-CRP水平和六个月全因死亡率之间存在显著的直接相关性.
- hs-CRP可以作为HF的有价值的预后指标.
- 常规hs-CRP测量可以改善风险分层,并指导HF患者的治疗决策.
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