在孕产妇多药的背景下,安全使用母乳作为产前药:改善实践的框架
Dotan Shaniv1,2,3, Anne Smits4,5, Karel Allegaert5,6,7
1School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. dotan.shaniv@mail.huji.ac.il.
Pediatric research
|September 25, 2025
概括
哺乳期的母体多药,尤其是早产婴儿,缺乏证据. 这项研究提供了一个框架和策略,如:
科学领域:
- 药理学 药理学是指药理学的学科.
- 新生儿科学 新生儿科学
- 哺乳期研究 哺乳期研究
背景情况:
- 哺乳期母亲的药物治疗尚未得到充分研究,对早产婴儿的数据有限.
- 由于缺乏科学指导,哺乳期母亲的多药性对医疗保健提供者构成重大挑战.
- 评估母乳 (MOM) 对早产新生儿多药性潜在风险的益处需要仔细考虑.
研究的目的:
- 为改善临床和研究实践提供一个框架,以改善在早产婴儿的背景下,在哺乳期间对母亲的多药性治疗.
- 解决有关母亲使用多种药物的母乳安全性的知识差距.
- 支持在具有挑战性的临床场景中对母乳 (MOM) 的风险益处评估.
主要方法:
- 文献综述和现有证据的综合对母亲药物转移到母乳.
- 制定一个包含风险缓解策略的框架.
- 提出一个研究议程,以解决知识差距的建议.
主要成果:
- 有限证据表明母乳养期间的多药性治疗,特别是对于早产婴儿.
- 有几种策略可以尽量减少婴儿通过母乳接触药物,包括药物选择和"混合养".
- 提出了一个框架,以帮助临床决策和指导未来的研究.
结论:
- 哺乳期的多药性是很难理解的,需要改进临床指南和研究.
- 诸如选择低乳转移,相对安全等级和"混合养"的药物等策略可以减少婴儿暴露.
- 提供的框架旨在增强对面临孕产妇多药和早产的双胞胎母乳的安全供应.
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