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关于MDM2/MDMX抗瘤拼接PROTAC的设计,合成和活性的研究

Xiufei Liao1, Mao Guo1, Damin Hu1

  • 1School of Medicine, Tarim University, Xinjiang Uygur Autonomous Region, Alaer, 843300, China.

Scientific reports
|September 25, 2025
PubMed
概括

研究人员开发了双标合类PROTACs来降解促进癌症的蛋白质MDM2和MDMX. 这些新型的PROTAC通过增强蛋白质降解,显示出有前途的抗瘤活性,为癌症治疗提供了一种新的策略.

关键词:
这是一种抗瘤药物.这就是PROTAC.接质类的类.

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