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Updated: Jan 16, 2026

Induction and Analysis of Epithelial to Mesenchymal Transition

Induction and Analysis of Epithelial to Mesenchymal Transition

Published on: August 27, 2013

识别,功能洞察和EMT瘤状态的治疗向

Anqi Dong¹, Cédric Blanpain^2,3

¹Laboratory of Stem Cells and Cancer, Université Libre de Bruxelles (ULB), Brussels, Belgium.

Nature reviews. Cancer

|September 25, 2025

概括

在癌症中,表皮细胞到介质细胞的转换 (EMT) 涉及到动态的细胞状态,而不是简单的开关. 了解这些状态及其调节对于开发针对瘤进展和治疗耐药性的新疗法至关重要.

科学领域:

在瘤学瘤学.
细胞生物学细胞生物学
癌症研究癌症研究

背景情况:

皮质到介质细胞的过渡 (EMT) 对于瘤的开始,进展,转移和治疗耐药性至关重要.
EMT最初被视为一个二进制过程,但现在被理解为细胞状态的光谱.

研究的目的:

审查了解癌症中EMT的最新进展.
讨论不同分子和环境因素对不同EMT状态的调节.
突出EMT在抗癌疗法耐药性和新型治疗策略中的作用.

主要方法:

关于EMT研究近期科学进展的文献综述.
对基因调节网络,瘤突变,信号通路,转录因子,表观遗传调节剂和微环境线索的分析.
检查EMT驱动的治疗耐药性和新兴治疗点的基础机制.

主要成果:

EMT是一个复杂的过程,其特点是特定的利基内的多个瘤状态,每一个都有独特的功能性质.
这些EMT状态由由瘤突变,信号通路,转录因子,表观遗传修饰剂和微环境信号所影响的复杂的基因调节网络来调节.
医疗瘤疗法对抗癌症疗法的耐药性有显著的贡献,需要有针对性的干预措施.

结论:

EMT是一个多方面的细胞程序,对癌症进展和治疗挑战至关重要.
针对不同的EMT状态及其监管机制,为新型癌症治疗提供了有希望的途径.
对EMT可塑性和利基特定监管的进一步研究对于推进临床瘤学至关重要.

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